Dietary zinc deficiency reduced growth performance, intestinal immune and physical barrier functions related to NF-κB, TOR, Nrf2, JNK and MLCK signaling pathway of young grass carp (Ctenopharyngodon idella).
Identifieur interne : 000874 ( Main/Exploration ); précédent : 000873; suivant : 000875Dietary zinc deficiency reduced growth performance, intestinal immune and physical barrier functions related to NF-κB, TOR, Nrf2, JNK and MLCK signaling pathway of young grass carp (Ctenopharyngodon idella).
Auteurs : Zheng-Xing Song [République populaire de Chine] ; Wei-Dan Jiang [République populaire de Chine] ; Yang Liu [République populaire de Chine] ; Pei Wu [République populaire de Chine] ; Jun Jiang [République populaire de Chine] ; Xiao-Qiu Zhou [République populaire de Chine] ; Sheng-Yao Kuang [République populaire de Chine] ; Ling Tang [République populaire de Chine] ; Wu-Neng Tang [République populaire de Chine] ; Yong-An Zhang [République populaire de Chine] ; Lin Feng [République populaire de Chine]Source :
- Fish & shellfish immunology [ 1095-9947 ] ; 2017.
Descripteurs français
- KwdFr :
- Aeromonas hydrophila (physiologie), Aliment pour animaux (analyse), Animaux (MeSH), Antioxydants (métabolisme), Carpes (poisson) (croissance et développement), Carpes (poisson) (immunologie), Compléments alimentaires (analyse), Immunité innée (MeSH), Infections bactériennes à Gram négatif (génétique), Infections bactériennes à Gram négatif (immunologie), Infections bactériennes à Gram négatif (microbiologie), Infections bactériennes à Gram négatif (médecine vétérinaire), Intestins (immunologie), Maladies des poissons (génétique), Maladies des poissons (immunologie), Maladies des poissons (microbiologie), Muqueuse intestinale (métabolisme), Protéines de poisson (génétique), Protéines de poisson (métabolisme), Relation dose-effet des médicaments (MeSH), Régime alimentaire (médecine vétérinaire), Répartition aléatoire (MeSH), Transduction du signal (MeSH), Zinc (déficit).
- MESH :
- analyse : Aliment pour animaux, Compléments alimentaires.
- croissance et développement : Carpes (poisson).
- déficit : Zinc.
- génétique : Infections bactériennes à Gram négatif, Maladies des poissons, Protéines de poisson.
- immunologie : Carpes (poisson), Infections bactériennes à Gram négatif, Intestins, Maladies des poissons.
- microbiologie : Infections bactériennes à Gram négatif, Maladies des poissons.
- médecine vétérinaire : Infections bactériennes à Gram négatif, Régime alimentaire.
- métabolisme : Antioxydants, Muqueuse intestinale, Protéines de poisson.
- physiologie : Aeromonas hydrophila.
- Animaux, Immunité innée, Relation dose-effet des médicaments, Répartition aléatoire, Transduction du signal.
English descriptors
- KwdEn :
- Aeromonas hydrophila (physiology), Animal Feed (analysis), Animals (MeSH), Antioxidants (metabolism), Carps (growth & development), Carps (immunology), Diet (veterinary), Dietary Supplements (analysis), Dose-Response Relationship, Drug (MeSH), Fish Diseases (genetics), Fish Diseases (immunology), Fish Diseases (microbiology), Fish Proteins (genetics), Fish Proteins (metabolism), Gram-Negative Bacterial Infections (genetics), Gram-Negative Bacterial Infections (immunology), Gram-Negative Bacterial Infections (microbiology), Gram-Negative Bacterial Infections (veterinary), Immunity, Innate (MeSH), Intestinal Mucosa (metabolism), Intestines (immunology), Random Allocation (MeSH), Signal Transduction (MeSH), Zinc (deficiency).
- MESH :
- chemical , deficiency : Zinc.
- chemical , genetics : Fish Proteins.
- chemical , metabolism : Antioxidants, Fish Proteins.
- analysis : Animal Feed, Dietary Supplements.
- genetics : Fish Diseases, Gram-Negative Bacterial Infections.
- growth & development : Carps.
- immunology : Carps, Fish Diseases, Gram-Negative Bacterial Infections, Intestines.
- metabolism : Intestinal Mucosa.
- microbiology : Fish Diseases, Gram-Negative Bacterial Infections.
- physiology : Aeromonas hydrophila.
- veterinary : Diet, Gram-Negative Bacterial Infections.
- Animals, Dose-Response Relationship, Drug, Immunity, Innate, Random Allocation, Signal Transduction.
Abstract
Our study investigated the effects of dietary zinc (Zn) deficiency on growth performance, intestinal immune and physical barrier functions of young grass carp (Ctenopharyngodon idella). A total of 630 grass carp (244.14 ± 0.40 g) were fed graded levels of zinc lactate (10.71, 30.21, 49.84, 72.31, 92.56, 110.78 mg Zn/kg diet) and one zinc sulfate group (56.9 mg Zn/kg diet) for 60 days. At the end of the feeding trial, fish were challenged with Aeromonas hydrophila for 14 days. These results indicated that compared with optimal dietary Zn level, dietary Zn deficiency (10.71 mg/kg diet) decreased the production of antibacterial compounds, up-regulated pro-inflammatory cytokines related to nuclear factor kappa B (NF-κB) and down-regulated anti-inflammatory cytokines related to target of rapamycin (TOR) in three intestinal segments of young grass carp (P < 0.05), suggesting that dietary Zn deficiency could impair intestinal immune barrier of fish; decreased the activities and mRNA levels of antioxidant enzymes related to NF-E2-related factor 2 (Nrf2), up-regulated the mRNA levels of caspase-3, -7, -8, -9 related to p38 mitogen activated protein (p38 MAPK) and c-Jun N-terminal protein kinase (JNK), down-regulated the mRNA levels of tight junction complexes (TJs) related to myosin light chain kinase (MLCK) in three intestinal segments of young grass carp (P < 0.05), demonstrating that dietary Zn deficiency could injury intestinal physical barrier of fish. Besides, the Zn requirements (zinc lactate as Zn source) based on percent weight gain (PWG), against enteritis morbidity, acid phosphatase (ACP) activity in the proximal intestine (PI) and malondialdehyde (MDA) content in the PI of young grass carp was estimated to be 61.2, 61.4, 69.2 and 69.5 mg/kg diet, respectively. Finally, based on specific growth rate (SGR), feed efficiency (FE) and against enteritis morbidity of young grass carp, the efficacy of zinc lactate relative to zinc sulfate were 132.59%, 135.27% and 154.04%, respectively.
DOI: 10.1016/j.fsi.2017.05.048
PubMed: 28549941
Affiliations:
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Le document en format XML
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Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Pei" sort="Wu, Pei" uniqKey="Wu P" first="Pei" last="Wu">Pei Wu</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Jun" sort="Jiang, Jun" uniqKey="Jiang J" first="Jun" last="Jiang">Jun Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Xiao Qiu" sort="Zhou, Xiao Qiu" uniqKey="Zhou X" first="Xiao-Qiu" last="Zhou">Xiao-Qiu Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Kuang, Sheng Yao" sort="Kuang, Sheng Yao" uniqKey="Kuang S" first="Sheng-Yao" last="Kuang">Sheng-Yao Kuang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066</wicri:regionArea><wicri:noRegion>Chengdu 610066</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Ling" sort="Tang, Ling" uniqKey="Tang L" first="Ling" last="Tang">Ling Tang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066</wicri:regionArea><wicri:noRegion>Chengdu 610066</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Wu Neng" sort="Tang, Wu Neng" uniqKey="Tang W" first="Wu-Neng" last="Tang">Wu-Neng Tang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066</wicri:regionArea><wicri:noRegion>Chengdu 610066</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yong An" sort="Zhang, Yong An" uniqKey="Zhang Y" first="Yong-An" last="Zhang">Yong-An Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China. 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Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Pei" sort="Wu, Pei" uniqKey="Wu P" first="Pei" last="Wu">Pei Wu</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Jun" sort="Jiang, Jun" uniqKey="Jiang J" first="Jun" last="Jiang">Jun Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Xiao Qiu" sort="Zhou, Xiao Qiu" uniqKey="Zhou X" first="Xiao-Qiu" last="Zhou">Xiao-Qiu Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Kuang, Sheng Yao" sort="Kuang, Sheng Yao" uniqKey="Kuang S" first="Sheng-Yao" last="Kuang">Sheng-Yao Kuang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066</wicri:regionArea><wicri:noRegion>Chengdu 610066</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Ling" sort="Tang, Ling" uniqKey="Tang L" first="Ling" last="Tang">Ling Tang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066</wicri:regionArea><wicri:noRegion>Chengdu 610066</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Wu Neng" sort="Tang, Wu Neng" uniqKey="Tang W" first="Wu-Neng" last="Tang">Wu-Neng Tang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066</wicri:regionArea><wicri:noRegion>Chengdu 610066</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yong An" sort="Zhang, Yong An" uniqKey="Zhang Y" first="Yong-An" last="Zhang">Yong-An Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China. Electronic address: fenglin@sicau.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author></analytic><series><title level="j">Fish & shellfish immunology</title><idno type="eISSN">1095-9947</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aeromonas hydrophila (physiology)</term><term>Animal Feed (analysis)</term><term>Animals (MeSH)</term><term>Antioxidants (metabolism)</term><term>Carps (growth & development)</term><term>Carps (immunology)</term><term>Diet (veterinary)</term><term>Dietary Supplements (analysis)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Fish Diseases (genetics)</term><term>Fish Diseases (immunology)</term><term>Fish Diseases (microbiology)</term><term>Fish Proteins (genetics)</term><term>Fish Proteins (metabolism)</term><term>Gram-Negative Bacterial Infections (genetics)</term><term>Gram-Negative Bacterial Infections (immunology)</term><term>Gram-Negative Bacterial Infections (microbiology)</term><term>Gram-Negative Bacterial Infections (veterinary)</term><term>Immunity, Innate (MeSH)</term><term>Intestinal Mucosa (metabolism)</term><term>Intestines (immunology)</term><term>Random Allocation (MeSH)</term><term>Signal Transduction (MeSH)</term><term>Zinc (deficiency)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aeromonas hydrophila (physiologie)</term><term>Aliment pour animaux (analyse)</term><term>Animaux (MeSH)</term><term>Antioxydants (métabolisme)</term><term>Carpes (poisson) (croissance et développement)</term><term>Carpes (poisson) (immunologie)</term><term>Compléments alimentaires (analyse)</term><term>Immunité innée (MeSH)</term><term>Infections bactériennes à Gram négatif (génétique)</term><term>Infections bactériennes à Gram négatif (immunologie)</term><term>Infections bactériennes à Gram négatif (microbiologie)</term><term>Infections bactériennes à Gram négatif (médecine vétérinaire)</term><term>Intestins (immunologie)</term><term>Maladies des poissons (génétique)</term><term>Maladies des poissons (immunologie)</term><term>Maladies des poissons (microbiologie)</term><term>Muqueuse intestinale (métabolisme)</term><term>Protéines de poisson (génétique)</term><term>Protéines de poisson (métabolisme)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Régime alimentaire (médecine vétérinaire)</term><term>Répartition aléatoire (MeSH)</term><term>Transduction du signal (MeSH)</term><term>Zinc (déficit)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Zinc</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fish Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term><term>Fish Proteins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Aliment pour animaux</term><term>Compléments alimentaires</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Animal Feed</term><term>Dietary Supplements</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Carpes (poisson)</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Zinc</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Fish Diseases</term><term>Gram-Negative Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Carps</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections bactériennes à Gram négatif</term><term>Maladies des poissons</term><term>Protéines de poisson</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Carpes (poisson)</term><term>Infections bactériennes à Gram négatif</term><term>Intestins</term><term>Maladies des poissons</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carps</term><term>Fish Diseases</term><term>Gram-Negative Bacterial Infections</term><term>Intestines</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Intestinal Mucosa</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections bactériennes à Gram négatif</term><term>Maladies des poissons</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Fish Diseases</term><term>Gram-Negative Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections bactériennes à Gram négatif</term><term>Régime alimentaire</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antioxydants</term><term>Muqueuse intestinale</term><term>Protéines de poisson</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Aeromonas hydrophila</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aeromonas hydrophila</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Diet</term><term>Gram-Negative Bacterial Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Immunity, Innate</term><term>Random Allocation</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Immunité innée</term><term>Relation dose-effet des médicaments</term><term>Répartition aléatoire</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our study investigated the effects of dietary zinc (Zn) deficiency on growth performance, intestinal immune and physical barrier functions of young grass carp (Ctenopharyngodon idella). A total of 630 grass carp (244.14 ± 0.40 g) were fed graded levels of zinc lactate (10.71, 30.21, 49.84, 72.31, 92.56, 110.78 mg Zn/kg diet) and one zinc sulfate group (56.9 mg Zn/kg diet) for 60 days. At the end of the feeding trial, fish were challenged with Aeromonas hydrophila for 14 days. These results indicated that compared with optimal dietary Zn level, dietary Zn deficiency (10.71 mg/kg diet) decreased the production of antibacterial compounds, up-regulated pro-inflammatory cytokines related to nuclear factor kappa B (NF-κB) and down-regulated anti-inflammatory cytokines related to target of rapamycin (TOR) in three intestinal segments of young grass carp (P < 0.05), suggesting that dietary Zn deficiency could impair intestinal immune barrier of fish; decreased the activities and mRNA levels of antioxidant enzymes related to NF-E2-related factor 2 (Nrf2), up-regulated the mRNA levels of caspase-3, -7, -8, -9 related to p38 mitogen activated protein (p38 MAPK) and c-Jun N-terminal protein kinase (JNK), down-regulated the mRNA levels of tight junction complexes (TJs) related to myosin light chain kinase (MLCK) in three intestinal segments of young grass carp (P < 0.05), demonstrating that dietary Zn deficiency could injury intestinal physical barrier of fish. Besides, the Zn requirements (zinc lactate as Zn source) based on percent weight gain (PWG), against enteritis morbidity, acid phosphatase (ACP) activity in the proximal intestine (PI) and malondialdehyde (MDA) content in the PI of young grass carp was estimated to be 61.2, 61.4, 69.2 and 69.5 mg/kg diet, respectively. Finally, based on specific growth rate (SGR), feed efficiency (FE) and against enteritis morbidity of young grass carp, the efficacy of zinc lactate relative to zinc sulfate were 132.59%, 135.27% and 154.04%, respectively.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28549941</PMID><DateCompleted><Year>2017</Year><Month>11</Month><Day>24</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9947</ISSN><JournalIssue CitedMedium="Internet"><Volume>66</Volume><PubDate><Year>2017</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Fish & shellfish immunology</Title><ISOAbbreviation>Fish Shellfish Immunol</ISOAbbreviation></Journal><ArticleTitle>Dietary zinc deficiency reduced growth performance, intestinal immune and physical barrier functions related to NF-κB, TOR, Nrf2, JNK and MLCK signaling pathway of young grass carp (Ctenopharyngodon idella).</ArticleTitle><Pagination><MedlinePgn>497-523</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1050-4648(17)30293-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.fsi.2017.05.048</ELocationID><Abstract><AbstractText>Our study investigated the effects of dietary zinc (Zn) deficiency on growth performance, intestinal immune and physical barrier functions of young grass carp (Ctenopharyngodon idella). A total of 630 grass carp (244.14 ± 0.40 g) were fed graded levels of zinc lactate (10.71, 30.21, 49.84, 72.31, 92.56, 110.78 mg Zn/kg diet) and one zinc sulfate group (56.9 mg Zn/kg diet) for 60 days. At the end of the feeding trial, fish were challenged with Aeromonas hydrophila for 14 days. These results indicated that compared with optimal dietary Zn level, dietary Zn deficiency (10.71 mg/kg diet) decreased the production of antibacterial compounds, up-regulated pro-inflammatory cytokines related to nuclear factor kappa B (NF-κB) and down-regulated anti-inflammatory cytokines related to target of rapamycin (TOR) in three intestinal segments of young grass carp (P < 0.05), suggesting that dietary Zn deficiency could impair intestinal immune barrier of fish; decreased the activities and mRNA levels of antioxidant enzymes related to NF-E2-related factor 2 (Nrf2), up-regulated the mRNA levels of caspase-3, -7, -8, -9 related to p38 mitogen activated protein (p38 MAPK) and c-Jun N-terminal protein kinase (JNK), down-regulated the mRNA levels of tight junction complexes (TJs) related to myosin light chain kinase (MLCK) in three intestinal segments of young grass carp (P < 0.05), demonstrating that dietary Zn deficiency could injury intestinal physical barrier of fish. Besides, the Zn requirements (zinc lactate as Zn source) based on percent weight gain (PWG), against enteritis morbidity, acid phosphatase (ACP) activity in the proximal intestine (PI) and malondialdehyde (MDA) content in the PI of young grass carp was estimated to be 61.2, 61.4, 69.2 and 69.5 mg/kg diet, respectively. Finally, based on specific growth rate (SGR), feed efficiency (FE) and against enteritis morbidity of young grass carp, the efficacy of zinc lactate relative to zinc sulfate were 132.59%, 135.27% and 154.04%, respectively.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Zheng-Xing</ForeName><Initials>ZX</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Wei-Dan</ForeName><Initials>WD</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Pei</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Xiao-Qiu</ForeName><Initials>XQ</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuang</LastName><ForeName>Sheng-Yao</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Ling</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Wu-Neng</ForeName><Initials>WN</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu 610066, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yong-An</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Sichuan, Chengdu 611130, China. Electronic address: fenglin@sicau.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Fish Shellfish Immunol</MedlineTA><NlmUniqueID>9505220</NlmUniqueID><ISSNLinking>1050-4648</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029941">Fish Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>J41CSQ7QDS</RegistryNumber><NameOfSubstance UI="D015032">Zinc</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D016980" MajorTopicYN="N">Aeromonas hydrophila</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000821" MajorTopicYN="N">Animal Feed</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002347" MajorTopicYN="Y">Carps</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004032" MajorTopicYN="N">Diet</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="N">Dietary Supplements</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005393" MajorTopicYN="N">Fish Diseases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029941" MajorTopicYN="N">Fish Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016905" MajorTopicYN="N">Gram-Negative Bacterial Infections</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="Y">Immunity, Innate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007413" MajorTopicYN="N">Intestinal Mucosa</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015032" MajorTopicYN="N">Zinc</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="Y">deficiency</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Efficacy</Keyword><Keyword MajorTopicYN="N">Grass carp (Ctenopharyngodon idella)</Keyword><Keyword MajorTopicYN="N">Intestinal immune barrier</Keyword><Keyword MajorTopicYN="N">Physical barrier</Keyword><Keyword MajorTopicYN="N">Zinc</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>12</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>11</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28549941</ArticleId><ArticleId IdType="pii">S1050-4648(17)30293-0</ArticleId><ArticleId IdType="doi">10.1016/j.fsi.2017.05.048</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Song, Zheng Xing" sort="Song, Zheng Xing" uniqKey="Song Z" first="Zheng-Xing" last="Song">Zheng-Xing Song</name></noRegion><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><name sortKey="Jiang, Jun" sort="Jiang, Jun" uniqKey="Jiang J" first="Jun" last="Jiang">Jun Jiang</name><name sortKey="Jiang, Wei Dan" sort="Jiang, Wei Dan" uniqKey="Jiang W" first="Wei-Dan" last="Jiang">Wei-Dan Jiang</name><name sortKey="Kuang, Sheng Yao" sort="Kuang, Sheng Yao" uniqKey="Kuang S" first="Sheng-Yao" last="Kuang">Sheng-Yao Kuang</name><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><name sortKey="Tang, Ling" sort="Tang, Ling" uniqKey="Tang L" first="Ling" last="Tang">Ling Tang</name><name sortKey="Tang, Wu Neng" sort="Tang, Wu Neng" uniqKey="Tang W" first="Wu-Neng" last="Tang">Wu-Neng Tang</name><name sortKey="Wu, Pei" sort="Wu, Pei" uniqKey="Wu P" first="Pei" last="Wu">Pei Wu</name><name sortKey="Zhang, Yong An" sort="Zhang, Yong An" uniqKey="Zhang Y" first="Yong-An" last="Zhang">Yong-An Zhang</name><name sortKey="Zhou, Xiao Qiu" sort="Zhou, Xiao Qiu" uniqKey="Zhou X" first="Xiao-Qiu" last="Zhou">Xiao-Qiu Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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